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KMID : 0368820050440010050
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Journal of the Korean Neuropsychiatr Association
2005 Volume.44 No. 1 p.50 ~ p.57
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Comparison of the Effects between Olanzapine and Typical Antipsychotics on Social Functioning in Patients with Schizophrenia
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Kim Chul-Kwon
Chong Hyung-Mo
Choe Byeong-Moo
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Abstract
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Objectives: The purpose of this study was to compare the social functioning between schizophrenic patients treated with olanzapine and those with typical antipsychotics.
Methods: Fifty-seven schizophrenic patients with acute exacerbation entered consecutively to olanzapine treatment (N=33) or typical antipsychotic treatment (N=24). The assessment of social functioning and symptoms were made at 3 time points:at the time of admission (baseline), 6 months and 12 months after starting medications. Social functioning and symptoms were examined using the Korean version of Social Adjustment Scale II-Revised Version (KSAS II-RV) and the Positive and Negative Syndrome Scale (PANSS).
Results: After 6-months and 12-months treatments, olanzapine treatment group showed significantly improved PANSS total scores (p=.02), positive scores (p=.04), negative scores (p=.01), and KSAS II-RV total score (p=.004), instrumental role (p=.002), social leisure (p=.03), personal well-being subarea scores (p=.02), compared with the scores of typical antipsychotic treatment group.
Conclusion: Olanzapine was more effective than typical antipsychotics in reducing the severity of psychopathology and in improving some subareas of social functionings in patients with schizophrenia. The benefits of olanzapine on social functioning, although modest, may be important factor considering their accumulative effects for long-term treatment.
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KEYWORD
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Social functioning, Schizophrenia, Olanzapine, Atypical antipsychotics
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